inflammation disease — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9622	MF-766		Prostaglandin Receptor
	MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It...		Prostaglandin Receptor
T5310	TR-14035	MDK-1191	Integrin
	TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).		Integrin
T7644	DPN	Diarylpropionitrile	Apoptosis , Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Autophagy
	DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .
T6593	ML324		Histone Demethylase , Others , HSV
	ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).		Histone Demethylase , Others , HSV
T6561	Laquinimod	LAQ,ABR-215062	Apoptosis , Others , NF-κB
	Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy.		Apoptosis , Others , NF-κB
T1090	Perphenazine	Perphenazin,Etaperazine,Trilafon	CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T4583	PFI-2 hydrochloride	(R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.		Histone Methyltransferase
T9999	Sirtuin modulator 2	N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others , Sirtuin
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.		Others , Sirtuin
T0487	Metoprolol tartrate	CGP 2175E	Adrenergic Receptor
	Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor.		Adrenergic Receptor
T1987	PFI-2	PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase
	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.		Histone Methyltransferase
T12850	Dilmapimod	SB-681323,GW 681323	p38 MAPK , Autophagy
	Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.		p38 MAPK , Autophagy
TN1355	Acanthoside B		Immunology/Inflammation related
	Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.		Immunology/Inflammation related
T17289	ZED-1227	ZED-101,TAK-227	Others , Glutaminase
	ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease.		Others , Glutaminase
TMS2180	Zeaxanthin	Anchovyxanthin,All-Trans-Zeaxanthin	Antioxidant , Endogenous Metabolite
	1. Lutein and Zeaxanthin (All-Trans-Zeaxanthin) in neural tissue may have biological effects that include antioxidation, anti-inflammation, and structural actions. 2. Lutein and Zeaxanthin may be protective against eye d...		Antioxidant , Endogenous Metabolite
T78525	IRG1-IN-1		Others
	IRG1-IN-1 is an itaconic acid derivative with the ability to inhibit the activity of Immune Response Gene 1 (IRG1) and is suitable for use in the field of cancer, inflammation and autoimmune disease research.		Others
T11179	Elubrixin	SB-656933	IL Receptor , CXCR
	Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat...		IL Receptor , CXCR
T72031	BI 1015550		PDE
	BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo...		PDE
T38715	MSDC-0602K	MSDC-0602K,Azemiglitazone potassium	PPAR
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (...		PPAR
T24997	ABT-510 acetate	ABT 510 acetate	Apoptosis
	ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i...		Apoptosis